Test GNAS y KRAS en el diagnóstico de quistes pancreáticos
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2023-11-21
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Aunque muchos quistes, como pseudoquistes y quistadenomas serosos (SCA), tienen un curso clínico benigno, otros, como neoplasmas mucinosos papilares intraductales (IPMN) y neoplasmas quísticos mucinosos (MCN), representan lesiones precursoras del adenocarcinoma pancreático invasivo. La neoplasia mucinosa papilar intraductal del páncreas se caracteriza por una dilatación del conducto pancreático principal y / o los conductos secundarios, producción de mucina y ausencia de estroma de tipo ovárico. Los síntomas son inespecíficos y, en general, el diagnóstico es incidental. Debido a su riesgo de malignidad, se desarrollaron guías de consenso internacional para la gestión de IPMN y MCN y se actualizaron recientemente. Estas pautas de manejo se basan en la suposición de que los quistes mucinosos se pueden distinguir con precisión de otras lesiones quísticas pancreáticas.A pesar de estas medidas, la distinción preoperatoria de quistes pancreáticos entre sí es dificil y, si es incorrecta, puede representar un riesgo significativo para la salud del paciente. Estas pautas de manejo recomiendan el análisis del líquido del quiste en aquellos centros con experiencia en ultrasonido endoscópico y aspiración con aguja fina (EUS-FNA) e interpretación citológica. El objetivo de este proyecto es analizar las características moleculares de los quistes pancreáticos utilizando el líquido pancreático obtenido por aspiración en pacientes del Hospital El Cruce para poder identificar marcadores genéticos pronósticos que ayuden a los médicos en la toma de decisiones.
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Although many cysts, such as pseudocysts and serous cystadenomas (SCA), have a benign clinical course, others, such as intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN), represent precursor lesions of invasive pancreatic adenocarcinoma.Intraductal papillary mucinous papillary neoplasia of the pancreas is characterized by dilatation of the main pancreatic duct and / or secondary ducts, production of mucin and absence of ovarian-type stroma. The symptoms are non-specific and, in general, the diagnosis is incidental. Because of its risk of malignancy, an international consensus guide for the management of IPMN and MCN has been developed and updated recently.These management guidelines are based on the assumption that mucinous cysts can be accurately distinguished from other pancreatic cystic lesions.Despite these measures, the preoperative distinction of pancreatic cysts from each other is difficult and if it is incorrect, it may represent a significant risk to the patient's health. These management guidelines allowed the analysis of cyst fluid in centers with experience in endoscopic ultrasound and fine needle aspiration (EUS-FNA) and cytological interpretation.The objective of this project is to analyze the molecular characteristics of pancreatic cysts using pancreatic fluid obtained by aspiration in patients from Hospital El Cruce in order to identify prognostic genetic markers that help physicians make decisions.
Although many cysts, such as pseudocysts and serous cystadenomas (SCA), have a benign clinical course, others, such as intraductal papillary mucinous neoplasms (IPMN) and mucinous cystic neoplasms (MCN), represent precursor lesions of invasive pancreatic adenocarcinoma.Intraductal papillary mucinous papillary neoplasia of the pancreas is characterized by dilatation of the main pancreatic duct and / or secondary ducts, production of mucin and absence of ovarian-type stroma. The symptoms are non-specific and, in general, the diagnosis is incidental. Because of its risk of malignancy, an international consensus guide for the management of IPMN and MCN has been developed and updated recently.These management guidelines are based on the assumption that mucinous cysts can be accurately distinguished from other pancreatic cystic lesions.Despite these measures, the preoperative distinction of pancreatic cysts from each other is difficult and if it is incorrect, it may represent a significant risk to the patient's health. These management guidelines allowed the analysis of cyst fluid in centers with experience in endoscopic ultrasound and fine needle aspiration (EUS-FNA) and cytological interpretation.The objective of this project is to analyze the molecular characteristics of pancreatic cysts using pancreatic fluid obtained by aspiration in patients from Hospital El Cruce in order to identify prognostic genetic markers that help physicians make decisions.
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Marcadores genéticos, Cáncer pancreático, Quistes, Genetic markers, Pancreatic cáncer, Cysts
Citación
Ramirez, C. y Hwang, H. J. (2023). Test GNAS y KRAS en el diagnóstico de quistes pancreáticos. Contribuciones de Ciencia y Tecnología, 1(1). https://rid.unaj.edu.ar/handle/123456789/2837